Original Publications

115: Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri B.
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Nature. 2018 May;557(7706):580-584. doi: 10.1038/s41586-018-0125-z. Epub 2018 May 16. PubMed PMID: 29769727.

114: Klepsch V, Hermann-Kleiter N, Do-Dinh P, Jakic B, Offermann A, Efremova M, Sopper S, Rieder D, Krogsdam A, Gamerith G, Perner S, Tzankov A, Trajanoski Z, Wolf D, Baier G.
Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.
Nat Commun. 2018 Apr 18;9(1):1538. doi: 10.1038/s41467-018-04004-2. PubMed PMID: 29670099;

113: zur Nedden S, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, Koschak A, Cameron AJ, Parker PJ, Baier G, Baier-Bitterlich G.
Protein kinase N1 critically regulates cerebellar development and long-term function.
J Clin Invest. 2018 May 1;128(5):2076-2088. doi: 10.1172/JCI96165. Epub 2018 Apr 16. PubMed PMID: 29494346;

112: Efremova M, Rieder D, Klepsch V, Charotong P, Finotello F, Hackl H, Hermann-Kleiter N, Löwer M, Baier G, Krogsdam A, Trajanoski Z.
Targeting immunecheckpoints potentiates immunoediting and changes the dynamics of tumor evolution.
Nat Commun. 2018 Jan 2;9(1):32. doi: 10.1038/s41467-017-02424-0. PubMed PMID: 29296022.

111: Gerner RR, Klepsch V, Macheiner S, Arnhard K, Adolph TE, Grander C, Wieser V, Pfister A, Moser P, Hermann-Kleiter N, Baier G, Oberacher H, Tilg H, Moschen AR.
NAD metabolism fuels human and mouse intestinal inflammation.
Gut 2017, Sept. 6 pii: gutjnl-2017-314241. doi: 10.1136/gutjnl-2017-314241. PubMed PMID: 28877980.

110: Klepsch V, Gerner R., Klepsch S, Olson W, Tilg H, Moschen A, Baier G., Hermann-Kleiter N.
Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis.
Gut 2017, Aug 4. pii: gutjnl-2016-313466. doi: 10.1136/gutjnl-2016-313466. [Epub ahead of print] PubMed PMID: 28779026.

109: Peer S, Baier G, Gruber T.
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget. 2017 Jun 27;8(26):41841-41853. doi: 10.18632/oncotarget.18360. PubMed PMID: 28611299.

108: Siegmund K, Thuille N, Wachowicz K, Hermann-Kleiter N, Baier G.
Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.
PLoS One. 2017 May 22;12(5):e0175463. doi: 10.1371/journal.pone.0175463. eCollection 2017. PubMed PMID: 28531229; PubMed Central PMCID: PMC5439664.

107: Siegmund K, Klepsch V, Hermann-Kleiter N, Baier G.
Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.
J Biol Chem. 2016 Oct 14;291(42):22086-22092. PubMed PMID: 27566541; PubMed Central PMCID: PMC5063991.

106: Haller M, Khalid S, Kremser L, Fresser F, Furlan T, Hermann M, Guenther J, Drasche A, Leitges M, Giorgio M, Baier G, Lindner H, Troppmair J.
Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc.
J Biol Chem. 2016 Nov 4;291(45):23557-23568. PubMed PMID: 27624939; PubMed Central PMCID: PMC5095410.

105: Pfeifhofer-Obermair C, Albrecht-Schgoer K, Peer S, Nairz M, Siegmund K, Klepsch V, Thuille N, Hermann-Kleiter N, Gruber T, Weiss G, Baier G.
Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.
Cell Commun Signal. 2016 Jul 28;14(1):14. doi:10.1186/s12964-016-0137-y. PubMed PMID: 27465248; PubMed Central PMCID: PMC4964075.

104: Wirnsberger G, Zwolanek F, Asaoka T, Kozieradzki I, Tortola L, Wimmer RA, Kavirayani A, Fresser F, Baier G, Langdon WY, Ikeda F, Kuchler K, Penninger JM.
Inhibition of CBLB protects from lethal Candida albicans sepsis.
Nature Medicine 2016 Aug;22(8):915-23. doi: 10.1038/nm.4134. PubMed PMID: 27428901.

103: Khalid S, Drasche A, Thurner M, Hermann M, Ashraf MI, Fresser F, Baier G, Kremser L, Lindner H, Troppmair J.
cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.
Science Rep. 2016 Feb 12;6:20930. doi: 10.1038/srep20930. PubMed PMID: 26868434; PubMed Central PMCID: PMC4751440.

102: Hermann-Kleiter N, Klepsch V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G.
The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Cell Rep. 2015 Sep 16. pii: S2211-1247(15)00920-1.
doi:10.1016/j.celrep.2015.08.035. [Epub ahead of print] PubMed PMID: 26387951.

101: Siegmund K, Thuille N, Posch N, Fresser F, Baier G.
Novel protein kinase C theta: coronin 1A complex in T lymphocytes.
Cell Commun Signal. 2015 Mar 31;13:22.
doi: 10.1186/s12964-015-0100-3. PubMed PMID: 25889880; PubMed Central PMCID: PMC4390099.

100: Wachowicz K, Hermann-Kleiter N, Meisel M, Siegmund K, Thuille N, Baier G.
Protein Kinase C θ Regulates the Phenotype of Murine CD4+ Th17 Cells.
PLoS One. 2014 May 2;9(5):e96401.
doi: 10.1371/journal.pone.0096401. eCollection 2014. PubMed PMID: 24788550; PubMed Central PMCID: PMC4008503.

99: Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl BM, Penninger JM.
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Nature. 2014 Mar 27;507(7493):508-12.
doi: 10.1038/nature12998. Epub 2014 Feb 19. PubMed PMID:24553136.

98: Thauerer B, Voegele P, Hermann-Kleiter N, Thuille N, de Araujo ME, Offterdinger M, Baier G, Huber LA, Baier Bitterlich G.
LAMTOR2-Mediated Modulation of NGF/MAPK Activation Kinetics during Differentiation of PC12 Cells.
PLoS One. 2014 Apr 21;9(4):e95863. doi: 10.1371/journal.pone.0095863. eCollection 2014. PubMed PMID: 24752675; PubMed Central PMCID: PMC3994133.

97: Gruber T, Hinterleitner R, Hermann-Kleiter N, Meisel M, Kleiter I, Wang CM, Viola A, Pfeifhofer-Obermair C, Baier G.
Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
J Mol Cell Biol. 2013 Dec;5(6):358-68.

96: Wallner S, Lutz-Nicoladoni C, Tripp CH, Gastl G, Baier G, Penninger JM, Stoitzner P, Wolf D.
The role of the e3 ligase cbl-B in murine dendritic cells.
PLoS One. 2013 Jun 6;8(6):e65178.

95: Lutz-Nicoladoni C, Thuille N, Katarzyna W, Gruber T, Leitges M and Baier G.
PKCalpha and PKCbeta cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.
Immunol. Letters, 2013 Mar;151(1-2):31-8.

94: von Essen MR, Kongsbak M, Levring TB, Hansen AK, Boding L, Lauritsen JP, Woetmann A, Baier G, Odum N, Bonefeld CM, Geisler C.
PKCθ exists in an oxidized inactive form in naive human T cells.
Eur J Immunol. 2013, in press

93: Thuille N, Wachowicz K, Hermann-Kleiter N, Kaminski S, Fresser F, Lutz-Nicoladoni C, Leitges M, Thome M, Massoumi R & Baier G.
PKCtheta/beta and CYLD are antagonistic partners in the NFkappaB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.
PLoS One. 2013;8(1):e53709.

92: Meisel M, Hermann-Kleiter N, Hinterleitner R, Gruber T, Pfeifhofer-Obermair C, Fresser F, Leitges M, Soldani C, Viola A, Kaminski S, Baier G.
The kinase PKC alpha selectively upregulates interleukin-17A during Th17 cell immune responses.
Immunity, 2013 Jan 24;38(1):41-52.

91: Florian J. Bock1, Gerhard Krumschnabel1, Claudia Manzl1, Lukas Peintner1, Maria C. Tanzer1 Natascha Hermann-Kleiter2, Gottfried Baier2, Laura Llacuna3, Jose Yelamos3, and Andreas Villunger
Loss of PIDD limits NFκB activation and cytokine production but not cell survival or transformation after DNA-damage.
Cell Death Differ, 2013 Apr;20(4):546-57.

90: Hermann-Kleiter N, Meisel M, Fresser F, Thuille N, Muller M, Roth L, Katopodis A, Baier G.
Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORgammat binding to the Il17a promoter.
J Autoimmun. 2012. PMID: 22921335. [Epub ahead of print].

89: Hinterleitner R, Gruber T, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Tzankov A, Schuster M, Penninger JM, Loibner H, Lametschwandtner G, Wolf D, Baier G.
Adoptive Transfer of siRNA Cblb-Silenced CD8+ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model.
PLoS One. 2012. 7(9):e44295.

88: Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, Hopfner KP, Brombacher F, Urlaub H, Baier G, Brown GD, Leitges M, Ruland J.
Syk kinase-coupled C-type lectin receptors engage protein kinase C-sigma to elicit Card9 adaptor-mediated innate immunity.
Immunity. 2012. 36(1):32-42.

87: Kaminski S, Hermann-Kleiter N, Meisel M, Thuille N, Cronin S, Hara H, Fresser F, Penninger JM, Baier G.
Coronin 1A is an essential regulator of the TGFbeta receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells.
J Autoimmun. 2011 Nov;37(3):198-208.

86: Lutz-Nicoladoni C, Wallner S, Stoitzner P, Pircher M, Gruber T, Wolf AM, Gastl G, Penninger JM, Baier G, Wolf D.
Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8(+) T cells combined with a DC vaccine.
Immunol Cell Biol. 2011 Mar 8. [Epub ahead of print]

85: Paolino M, Thien CB, Gruber T, Hinterleitner R, Baier G, Langdon WY, Penninger JM.
Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions.
J Immunol. 2011 Feb 15;186(4):2138-47. Epub 2011 Jan 19.

84: Gruber T, Pfeifhofer-Obermair C, Baier G.
PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and and AP-1 during positive selection of thymocytes.
Immunol Lett. 2010 Aug 16;132(1-2):6-11.

83: Gruber T, Pfeifhofer-Obermair C andBaier G.
PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytes.
Immunology letters 2010;132(1-2):6-11.

82: Thuille N, Lutz-Nicoladoni C, Letschka T, Hermann-Kleiter N, Heit I, Baier G.
PKCtheta and Itk functionally interact during primary mouse CD3+ T cell activation.
Immunol Lett. 2009 Sep 22;126(1-2):54-9

81: Gruber T, Hermann-Kleiter N, Hinterleitner R, Fresser F, Schneider R, Gastl G, Penninger JM, Baier G.
PKC-{theta} Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation.
Science Signaling 2009 Jun 23;2(76):ra30.
PMID: 19549985 [PubMed - in process]

80: Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach K, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G.
The potent protein kinase C selective inhibitor AEB071 (Sotrastaurin)represents a new class of immunosuppressive agents affecting early T cell activation.
J Pharmacol Exp Ther. 2009 Jun 2. [Epub ahead of print]
PMID: 19491325 [PubMed - as supplied by publisher]

79: Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein-Hildesheim B, Wagner J, Leitges M, Baier G.
PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.
Mol Immunol. 2009 Jun;46(10):2071-9. Epub 2009 Apr 7.
PMID: 19356803 [PubMed - indexed for MEDLINE]

78: Letschka T, Kollmann V, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Obermair GJ, Fresser F, Leitges M, Hermann-Kleiter N, Kaminski S, Baier G.
PKC{theta} selectively controls the adhesion-stimulating molecule Rap1.
Blood. 2008 Sep 16. [Epub ahead of print]
PMID: 18796635 [PubMed - as supplied by publisher]

77: Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber LA, Villunger A, Eichele G, Kaminski S, Baier G.
The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity.
Immunity. 2008 Aug;29(2):205-16.
PMID: 18701084 [PubMed - in process]

76. Kiessling S, Lutz-Nicoladoni C, Olsson A, Niederegger H, Baier G, Villunger A.
Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of AKT1/PKBalpha.
Cell Death Differ. 2007 Jan;14(1):186-9.

75: Gruber T, Fresser F, Jenny M, Uberall F, Leitges M, Baier G.
PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes.
Mol Immunol. 2008 Jan;45(1):117-26. Epub 2007 Jun 22.
PMID: 17588663 [PubMed - indexed for MEDLINE]

74: Essen M, Nielsen MW, Bonefeld CM, Boding L, Larsen JM, Leitges M, Baier G, Odum N, Geisler C.
Protein Kinase C (PKC) alpha and PKCtheta are the major isotypes involved in TCR down-regulation.
J Immunol. 2006 Jun 15;176(12):7502-10.

73: Pfeifhofer C, Gruber T, Letschka T, Thuille N, Lutz-Nicoladoni C, Hermann-Kleiter N, Braun U, Leitges M, Baier G.
Defective IgG2a/2b Class Switching in PKCalpha-/- Mice.
J Immunol. 2006 May 15;176(10):6004-11.

72: Gruber T, Freeley M, Thuille N, Heit I, Shaw S, Long A, Baier G.
Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation".
Science. 2006 Apr 7;312(5770):55; author reply 55.

71: Hermann-Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schafer M, Zitt C, Hatzelmann A, Schudt C, Leitges M, Baier G.
PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.
Blood. 2006 Mar 2; [Epub ahead of print]

70: Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T.
Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation.
Mol Cell Biol. 2006 Mar;26(5):1806-16.

69: Thuille N, Heit I, Fresser F, Krumbock N, Bauer B, Leuthaeusser S, Dammeier S, Graham C, Copeland TD, Shaw S, Baier G.
Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.
EMBO J. 2005 Nov 16;24(22):3869-80. Epub 2005 Oct 27.

68: Jerkovic L, Voegele AF, Chwatal S, Kronenberg F, Radcliffe CM, Wormald MR, Lobentanz EM, Ezeh B, Eller P, Dejori N, Dieplinger B, Lottspeich F, Sattler W, Uhr M, Mechtler K, Dwek RA, Rudd PM, Baier G, Dieplinger H.
Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression.
J Proteome Res. 2005 May-Jun;4(3):889-99.

67: Lutz-Nicoladoni C, Letschka T, Leitges M, Villunger A, Baier G.
Essential Role of PKCdelta in Apoptosis Induction of Mouse Thymocytes.
American Journal of Immunology 1(1): 14-20, 2005
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66: Gruber T, Thuille N, Hermann-Kleiter N, Leitges M, Baier G.
Protein kinase Cepsilon is dispensable for TCR/CD3-signaling.
Mol Immunol. 2005 Feb;42(3):305-10.
PMID: 15589318 [PubMed - indexed for MEDLINE]

65: Gruber T, Barsig J, Pfeifhofer C, Ghaffari-Tabrizi N, Tinhofer I, Leitges M, Baier G.
PKCdelta is involved in signal attenuation in CD3+ T cells.
Immunol Lett. 2005 Jan 31;96(2):291-3.
PMID: 15585335 [PubMed - in process]

64: Mayr M, Chung YL, Mayr U, McGregor E, Troy H, Baier G, Leitges M, Dunn MJ, Griffiths JR, Xu Q.
Loss of PKC-delta alters cardiac metabolism.
Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H937-45.
PMID: 15277208 [PubMed - indexed for MEDLINE]

63: Thuille N, Gruber T, Bock G, Leitges M, Baier G.
Protein kinase C beta is dispensable for TCR-signaling.
Mol Immunol. 2004 Jun;41(4):385-90.
PMID: 15163535 [PubMed - indexed for MEDLINE]

62: Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, Penninger JM.
The MAGUK family protein CARD11 is essential for lymphocyte activation.
Immunity. 2003 Jun;18(6):763-75.
PMID: 12818158 [PubMed - indexed for MEDLINE]

61: Pfeifhofer C, Kofler K, Gruber T, Tabrizi NG, Lutz C, Maly K, Leitges M, Baier G.
Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells.
J Exp Med. 2003 Jun 2;197(11):1525-35. Erratum in: J Exp Med. 2003 Jul 7;198(1):183.
PMID: 12782715 [PubMed - indexed for MEDLINE]

60: Bauer B, Jenny M, Fresser F, Uberall F, Baier G.
AKT1/PKBalpha is recruited to lipid rafts and activated downstream of PKC isotypes in CD3-induced T cell signaling.
FEBS Lett. 2003 Apr 24;541(1-3):155-62.
PMID: 12706837 [PubMed - indexed for MEDLINE]

59: Lutz C, Nimpf J, Jenny M, Boecklinger K, Enzinger C, Utermann G, Baier-Bitterlich G, Baier G.
Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP).
J Biol Chem. 2002 Nov 8;277(45):43143-51. Epub 2002 Aug 21.
PMID: 12193592 [PubMed - indexed for MEDLINE]

58: Maly K, Strese K, Kampfer S, Ueberall F, Baier G, Ghaffari-Tabrizi N, Grunicke HH, Leitges M.
Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1.
FEBS Lett. 2002 Jun 19;521(1-3):205-10.
PMID: 12067706 [PubMed - indexed for MEDLINE]

57: Enzinger C, Wirleitner B, Lutz C, Bock G, Tomaselli B, Baier G, Fuchs D, Baier-Bitterlich G.
7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway.
Eur J Cell Biol. 2002 Apr;81(4):197-202.
PMID: 12018387 [PubMed - indexed for MEDLINE]

56: Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, Baier G, Masters CL, Beyreuther K, Evin G.
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
Biochemistry. 2002 Feb 26;41(8):2825-35.
PMID: 11851430 [PubMed - indexed for MEDLINE]

55: Kapetanopoulos A, Fresser F, Millonig G, Shaul Y, Baier G, Utermann G.
Direct interaction of the extracellular matrix protein DANCE with apolipoprotein(a) mediated by the kringle IV-type 2 domain.
Mol Genet Genomics. 2002 Jun;267(4):440-6. Epub 2002 May 25.
PMID: 12111551 [PubMed - indexed for MEDLINE]

54: Villalba M, Bi K, Hu J, Altman Y, Bushway P, Reits E, Neefjes J, Baier G, Abraham RT, Altman A.
Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C.
J Cell Biol. 2002 Apr 15;157(2):253-63. Epub 2002 Apr 15.
PMID: 11956228 [PubMed - indexed for MEDLINE]

53: Kofler K, Erdel M, Utermann G, Baier G.
Molecular genetics and structural genomics of the human protein kinase C gene module.
Genome Biol. 2002;3(3):RESEARCH0014. Epub 2002 Feb 27.
PMID: 11897026 [PubMed - indexed for MEDLINE]

52: Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, Ghaffari-Tabrizi N, Baier G, Hu Y, Xu Q.
Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice.
J Clin Invest. 2001 Nov;108(10):1505-12.
PMID: 11714742 [PubMed - indexed for MEDLINE]

51: Kampfer S, Windegger M, Hochholdinger F, Schwaiger W, Pestell RG, Baier G, Grunicke HH, Uberall F.
Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-Ras.
J Biol Chem. 2001 Nov 16;276(46):42834-42. Epub 2001 Sep 10.
PMID: 11551901 [PubMed - indexed for MEDLINE]

50: Wirleitner B, Czaputa R, Oettl K, Bock G, Widner B, Reibnegger G, Baier G, Fuchs D, Baier-Bitterlich G.
Induction of apoptosis by 7,8-dihydroneopterin: involvement of radical formation.
Immunobiology. 2001 May;203(4):629-41.
PMID: 11402497 [PubMed - indexed for MEDLINE]

49: Bauer B, Krumbock N, Fresser F, Hochholdinger F, Spitaler M, Simm A, Uberall F, Schraven B, Baier G.
Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells.
J Biol Chem. 2001 Aug 24;276(34):31627-34. Epub 2001 Jun 15.
PMID: 11410591 [PubMed - indexed for MEDLINE]

48: Wilda M, Ghaffari-Tabrizi N, Reisert I, Utermann G, Baier G, Hameister H.
Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development.
Mech Dev. 2001 May;103(1-2):197-200.
PMID: 11335134 [PubMed - indexed for MEDLINE]

47: Hass S, Weidemann A, Utermann G, Baier G.
Intracellular apolipoprotein E affects Amyloid Precursor Protein processing and amyloid Abeta production in COS-1 cells.
Mol Genet Genomics. 2001 Jul;265(5):791-800.
PMID: 11523796 [PubMed - indexed for MEDLINE]

46: Maulon L, Mari B, Bertolotto C, Ricci JE, Luciano F, Belhacene N, Deckert M, Baier G, Auberger P.
Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in Tcells. Role of P59Fyn and PKCepsilon.
Oncogene. 2001 Apr 12;20(16):1964-72.
PMID: 11360180 [PubMed - indexed for MEDLINE]

45: Schmarda A, Fresser F, Gschwentner M, Furst J, Ritter M, Lang F, Baier G, Paulmichl M.
Determination of protein-protein interactions of ICIn by the yeast two-hybrid system.
Cell Physiol Biochem. 2001;11(1):55-60.
PMID: 11275683 [PubMed - indexed for MEDLINE]

44: Bauer B, Krumbock N, Ghaffari-Tabrizi N, Kampfer S, Villunger A, Wilda M, Hameister H, Utermann G, Leitges M, Uberall F, Baier G.
T cell expressed PKCtheta demonstrates cell-type selective function.
Eur J Immunol. 2000 Dec;30(12):3645-54.
PMID: 11169407 [PubMed - indexed for MEDLINE]

43: Demeester N, Baier G, Enzinger C, Goethals M, Vandekerckhove J, Rosseneu M, Labeur C.
Apoptosis induced in neuronal cells by C-terminal amyloid beta-fragments is correlated with their aggregation properties in phospholipid membranes.
Mol Membr Biol. 2000 Oct-Dec;17(4):219-28.
PMID: 11302375 [PubMed - indexed for MEDLINE]

42: Klose R, Fresser F, Kochl S, Parson W, Kapetanopoulos A, Fruchart-Najib J, Baier G, Utermann G.
Mapping of a minimal apolipoprotein(a) interaction motif conserved in fibrin(ogen) beta - and gamma -chains.
J Biol Chem. 2000 Dec 8;275(49):38206-12.
PMID: 10980194 [PubMed - indexed for MEDLINE]

41: Bertolotto C, Maulon L, Filippa N, Baier G, Auberger P.
Protein kinase C theta and epsilon promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD.
J Biol Chem. 2000 Nov 24;275(47):37246-50.
PMID: 10976111 [PubMed - indexed for MEDLINE]

40: Hellbert K, Kampfer S, Maly K, Hochholdinger F, Mwanjewe J, Baier G, Uberall F, Grunicke HH.
Implication of atypical protein kinase C isozymes lambda and zeta in Ras mediated reorganization of the actin cytoskeleton and cyclin D1-induction.
Adv Enzyme Regul. 2000;40:49-62. Review. No abstract available.
PMID: 10828345 [PubMed - indexed for MEDLINE]

39: Hochholdinger F, Baier G, Nogalo A, Bauer B, Grunicke HH, Uberall F.
Novel membrane-targeted ERK1 and ERK2 chimeras which act as dominant negative, isotype-specific mitogen-activated protein kinase inhibitors of Ras-Raf-mediated transcriptional activation of c-fos in NIH 3T3 cells.
Mol Cell Biol. 1999 Dec;19(12):8052-65.
PMID: 10567531 [PubMed - indexed for MEDLINE]

38: Villunger A, Ghaffari-Tabrizi N, Tinhofer I, Krumbock N, Bauer B, Schneider T, Kasibhatla S, Greil R, Baier-Bitterlich G, Uberall F, Green DR, Baier G.
Synergistic action of protein kinase C theta and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells.
Eur J Immunol. 1999 Nov;29(11):3549-61.
PMID: 10556809 [PubMed - indexed for MEDLINE]

37: Uberall F, Hellbert K, Kampfer S, Maly K, Villunger A, Spitaler M, Mwanjewe J, Baier-Bitterlich G, Baier G, Grunicke HH.
Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton.
J Cell Biol. 1999 Feb 8;144(3):413-25.
PMID: 9971737 [PubMed - indexed for MEDLINE]

36: Ghaffari-Tabrizi N, Bauer B, Villunger A, Baier-Bitterlich G, Altman A, Utermann G, Uberall F, Baier G.
Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells.
Eur J Immunol. 1999 Jan;29(1):132-42.
PMID: 9933094 [PubMed - indexed for MEDLINE]

35: Kofler K, Kochl S, Parson W, Erdel M, Utermann G, Baier G.
Molecular characterization of the human protein kinase C theta gene locus (PRKCQ).
Mol Gen Genet. 1998 Sep;259(4):398-403.
PMID: 9790596 [PubMed - indexed for MEDLINE]

34: Kampfer S, Uberall F, Giselbrecht S, Hellbert K, Baier G, Grunicke HH.
Characterization of PKC isozyme specific functions in cellular signaling.
Adv Enzyme Regul. 1998;38:35-48. No abstract available.
PMID: 9762345 [PubMed - indexed for MEDLINE]

33: Kampfer S, Hellbert K, Villunger A, Doppler W, Baier G, Grunicke HH, Uberall F.
Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-lambda, epsilon and zeta.
EMBO J. 1998 Jul 15;17(14):4046-55.
PMID: 9670019 [PubMed - indexed for MEDLINE]

32: Hass S, Fresser F, Kochl S, Beyreuther K, Utermann G, Baier G.
Physical interaction of ApoE with amyloid precursor protein independent of the amyloid Abeta region in vitro.
J Biol Chem. 1998 May 29;273(22):13892-7.
PMID: 9593736 [PubMed - indexed for MEDLINE]

31: Kofler P, Wiesenhofer B, Rehrl C, Baier G, Stockhammer G, Humpel C.
Liposome-mediated gene transfer into established CNS cell lines, primary glial cells, and in vivo.
Cell Transplant. 1998 Mar-Apr;7(2):175-85.
PMID: 9588599 [PubMed - indexed for MEDLINE]

30: Kochl S, Fresser F, Lobentanz E, Baier G, Utermann G.
Novel interaction of apolipoprotein(a) with beta-2 glycoprotein I mediated by the kringle IV domain.
Blood. 1997 Aug 15;90(4):1482-9.
PMID: 9269765 [PubMed - indexed for MEDLINE]

29: Uberall F, Giselbrecht S, Hellbert K, Fresser F, Bauer B, Gschwendt M, Grunicke HH, Baier G.
Conventional PKC-alpha, novel PKC-epsilon and PKC-theta, but not atypical PKC-lambda are MARCKS kinases in intact NIH 3T3 fibroblasts.
J Biol Chem. 1997 Feb 14;272(7):4072-8.
PMID: 9020116 [PubMed - indexed for MEDLINE]

28: Baier-Bitterlich G, Fuchs D, Zangerle R, Baeuerle PA, Werner ER, Fresser F, Uberall F, Baier G, Wachter H.
trans-Activation of the HIV type 1 promoter by 7,8-dihydroneopterin in vitro.
AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):173-8.
PMID: 9007202 [PubMed - indexed for MEDLINE]

27: Baier-Bitterlich G, Baier G, Fuchs D, Bock G, Hausen A, Utermann G, Pavelka M, Wachter H.
Role of 7,8-dihydroneopterin in T-cell apoptosis and HTLV-1 transcription in vitro.
Oncogene. 1996 Nov 21;13(10):2281-5.
PMID: 8950996 [PubMed - indexed for MEDLINE]

26: Meller N, Liu YC, Collins TL, Bonnefoy-Berard N, Baier G, Isakov N, Altman A.
Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function.
Mol Cell Biol. 1996 Oct;16(10):5782-91.
PMID: 8816492 [PubMed - indexed for MEDLINE]

25: Baier-Bitterlich G, Uberall F, Bauer B, Fresser F, Wachter H, Grunicke H, Utermann G, Altman A, Baier G.
Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes.
Mol Cell Biol. 1996 Apr;16(4):1842-50.
PMID: 8657160 [PubMed - indexed for MEDLINE]

24: Onda T, LaFace D, Baier G, Brunner T, Honma N, Mikayama T, Altman A, Green DR.
A phage display system for detection of T cell receptor-antigen interactions.
Mol Immunol. 1995 Dec;32(17-18):1387-97.
PMID: 8643108 [PubMed - indexed for MEDLINE]

23: Onda T, Messier H, Bissonette R, Echeverri F, Baier G, Fotedar A, Green DR.
Antigen-specific immunoregulatory activity of a T cell receptor alpha chain generated by expression PCR.
Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):356-8. No abstract available.
PMID: 7613171 [PubMed - indexed for MEDLINE]

22: Gulbins E, Bissonnette R, Mahboubi A, Martin S, Nishioka W, Brunner T, Baier G, Baier-Bitterlich G, Byrd C, Lang F, et al.
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway.
Immunity. 1995 Apr;2(4):341-51.
PMID: 7536620 [PubMed - indexed for MEDLINE]

21: Baier G, Baier-Bitterlich G, Looney DJ, Altman A.
Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin
D antibody Fab fragments in vitro.
J Virol. 1995 Apr;69(4):2357-65.
PMID: 7533857 [PubMed - indexed for MEDLINE]

20: Onda T, Brunner T, Messier H, Bissonnette R, Echeverri F, Baier G, Fotedar A, Green DR.
Immunoregulatory activity of a T-cell receptor alpha chain demonstrated by in vitro transcription and translation.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3004-8.
PMID: 7708764 [PubMed - indexed for MEDLINE]

19: Baier-Bitterlich G, Baier G, Gulbins E, Coggeshall KM, Altman A.
The role of p56lck in CD4-mediated suppression of CD3-induced early signaling events in T lymphocytes.
Life Sci. 1995 Mar 3;56(15):1287-97.
PMID: 8614246 [PubMed - indexed for MEDLINE]

18: Erdel M, Baier-Bitterlich G, Duba C, Isakov N, Altman A, Utermann G, Baier G.
Mapping of the human protein kinase C-theta (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH.
Genomics. 1995 Jan 20;25(2):595-7. No abstract available.
PMID: 7790001 [PubMed - indexed for MEDLINE]

17: Baier G, Baier-Bitterlich G, Meller N, Coggeshall KM, Giampa L, Telford D, Isakov N, Altman A.
Expression and biochemical characterization of human protein kinase C-theta.
Eur J Biochem. 1994 Oct 1;225(1):195-203.
PMID: 7925438 [PubMed - indexed for MEDLINE]

16: Baier G, Coggeshall KM, Baier-Bitterlich G, Giampa L, Telford D, Herbert E, Shih W, Altman A.
Construction and characterization of lck- and fyn-specific tRNA: ribozyme chimeras.
Mol Immunol. 1994 Aug;31(12):923-32.
PMID: 8065375 [PubMed - indexed for MEDLINE]

15: Couture C, Baier G, Oetken C, Williams S, Telford D, Marie-Cardine A, Baier-Bitterlich G, Fischer S, Burn P, Altman A, et al.
Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation.
Mol Cell Biol. 1994 Aug;14(8):5249-58.
PMID: 7518561 [PubMed - indexed for MEDLINE]

14: Baier G, Baier-Bitterlich G, Couture C, Telford D, Giampa L, Altman A.
An efficient expression, purification and immunodetection system for recombinant gene products.
Biotechniques. 1994 Jul;17(1):94, 96, 98-9.
PMID: 7946324 [PubMed - indexed for MEDLINE]

13: Couture C, Baier G, Altman A, Mustelin T.
p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation.
Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5301-5.
PMID: 7515496 [PubMed - indexed for MEDLINE]

12: Gulbins E, Coggeshall KM, Baier G, Telford D, Langlet C, Baier-Bitterlich G, Bonnefoy-Berard N, Burn P, Wittinghofer A, Altman A.
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.
Mol Cell Biol. 1994 Jul;14(7):4749-58.
PMID: 7516472 [PubMed - indexed for MEDLINE]

11: Gulbins E, Coggeshall KM, Langlet C, Baier G, Bonnefoy-Berard N, Burn P, Wittinghofer A, Katzav S, Altman A.
Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.
Mol Cell Biol. 1994 Feb;14(2):906-13.
PMID: 8289830 [PubMed - indexed for MEDLINE]

10: Baier-Bitterlich G, Rappaport J, Baier G, Looney D, Wong-Staal F.
Transcellular activation of the HTLV promoter by human hematopoietic cells.
Oncogene. 1994 Jan;9(1):319-22.
PMID: 8302596 [PubMed - indexed for MEDLINE]

9: von Willebrand M, Baier G, Couture C, Burn P, Mustelin T.
Activation of phosphatidylinositol-3-kinase in Jurkat T cells depends on the presence of the p56lck tyrosine kinase.
Eur J Immunol. 1994 Jan;24(1):234-8.
PMID: 8020561 [PubMed - indexed for MEDLINE]

8: Gulbins E, Langlet C, Baier G, Bonnefoy-Berard N, Herbert E, Altman A, Coggeshall KM.
Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells.
J Immunol. 1994 Mar 1;152(5):2123-9.
PMID: 8133029 [PubMed - indexed for MEDLINE]

7: Gulbins E, Coggeshall KM, Baier G, Katzav S, Burn P, Altman A.
Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.
Science. 1993 May 7;260(5109):822-5.
PMID: 8484124 [PubMed - indexed for MEDLINE]

6: Yamada N, Kawakami Y, Kimura H, Fukamachi H, Baier G, Altman A, Kato T, Inagaki Y, Kawakami T.
Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells.
Biochem Biophys Res Commun. 1993 Apr 15;192(1):231-40.
PMID: 8476425 [PubMed - indexed for MEDLINE]

5: Baier G, Telford D, Gulbins E, Yamada N, Kawakami T, Altman A.
Improved specificity of RT-PCR amplifications using nested cDNA primers.
Nucleic Acids Res. 1993 Mar 11;21(5):1329-30. No abstract available.
PMID: 7681946 [PubMed - indexed for MEDLINE]

4: Baier G, Telford D, Giampa L, Coggeshall KM, Baier-Bitterlich G, Isakov N, Altman A.
Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.
J Biol Chem. 1993 Mar 5;268(7):4997-5004.
PMID: 8444877 [PubMed - indexed for MEDLINE]

3: Baier G, Piendl W, Redl B, Stoffler G.
Structure, organization and evolution of the L1 equivalent ribosomal protein gene of the archaebacterium Methanococcus vannielii.
Nucleic Acids Res. 1990 Feb 25;18(4):719-24.
PMID: 2107529 [PubMed - indexed for MEDLINE]

2: Wollensak G, Mur E, Mayr A, Baier G, Gottinger W, Stoffler G.
Effective methods for the investigation of human tear film proteins and lipids.
Graefes Arch Clin Exp Ophthalmol. 1990;228(1):78-82.
PMID: 2311948 [PubMed - indexed for MEDLINE]

1: Kopke AK, Baier G, Wittmann-Liebold B.
An archaebacterial gene from Methanococcus vannielii encoding a protein homologous to the ribosomal protein L10 family.
FEBS Lett. 1989 Apr 24;247(2):167-72.
PMID: 2497026 [PubMed - indexed for MEDLINE]

Reviews/Book Chapters

1: Altman A, Isakov N, Baier G.
Protein kinase Ctheta: a new essential superstar on the T-cell stage.
Immunol Today. 2000 Nov;21(11):567-73. Review.
PMID: 11094261 [PubMed - indexed for MEDLINE]

2: Grunicke HH, Kampfer S, Spitaler M, Hochholdinger F, Baier G, Uberall F.
Elements of signal transduction in drug discovery with special reference to inhibitors of protein kinase C.
Ernst Schering Res Found Workshop. 2001;(34):81-99.
PMID: 11394049 [PubMed - indexed for MEDLINE]

3: Leo A, Wienands J, Baier G, Horejsi V, Schraven B.
Adapters in lymphocyte signaling.
J Clin Invest. 2002 Feb;109(3):301-9. Review. No abstract available.
PMID: 11827988 [PubMed - indexed for MEDLINE]

4: Bauer B, Baier G.
Protein kinase C and AKT/protein kinase B in CD4+ T-lymphocytes: new partners
in TCR/CD28 signal integration.
Mol Immunol. 2002 Jun;38(15):1087-99. Review.
PMID: 12044776 [PubMed - indexed for MEDLINE]

5. Baier G.
„The PKC Gene Module - Cellular functions in T lymphocytes“
chapter 15, Protein Kinase C book 2003, 2ed, ed. L. Dekker, Landes Biosciences. USA

6 : Baier G.
"The PKC gene module: molecular biosystematics to resolve its T cell functions."
Immunol. Rev. 2003; T cell issue Vol. 192, 64-79.
PMID: 12670396 [PubMed - indexed for MEDLINE]

7. Thuille N, Gruber T, Pfeifhofer C, Hermann-Kleiter N, Lutz C, Letschka T, Leitges M and Baier G.
Physiological and non-redundant functions of PKC isotypes in Tlymphocytes.
Current Immunology Reviews, Vol. 2, No. 2. (May 2006), pp. 157-167

8. Baier G, Asadullah K, Zugel U.
The immunological synapse: Kinases in T cell signalling as potential drug targets.
Immunol Lett. 2006 Jan 30; [Epub ahead of print]

9. Baier G.
PKC isotype functions in T lymphocytes.
Ernst Schering Found Symp Proc. 2007;(3):29-41. Review.
PMID: 18510097 [PubMed - indexed for MEDLINE]

10. Baier G, Wagner J.
PKC inhibitors: potential in T cell-dependent immune diseases.
Curr Opin Cell Biol. 2009 Apr;21(2):262-7. Epub 2009 Feb 3. Review.
PMID: 19195860 [PubMed - indexed for MEDLINE]

11. Hermann-Kleiter N, Baier G.
NFAT pulls the strings during CD4+ T helper cell effector functions.
Blood. 2010 Jan 26.
PMID: 20103781 [Epub ahead of print]

12. Wallner S, Gruber T, Baier G, Wolf D.
Releasing the brake: targeting Cbl-b to enhance lymphocyte effector functions.
Clin Dev Immunol. 2012. 2012:692639.

13. Pfeifhofer-Obermair C, Thuille N, Baier G.
Involvement of distinct PKC gene products in T cell functions.
Front Immunol. 2012. 3:220. doi: 10.3389/fimmu.2012.00220.

14. Gruber T, Hinterleitner R, Pfeifhofer-Obermair C., Wolf D., and Baier G.
Engineering effective T cell based anti-tumor immunity.
2013 Feb 1;2(2):e22893.

15: Wachowicz K, Baier G.
Protein kinase C theta: the pleiotropic T-cell signalling intermediate.
Biochem Soc Trans. 2014 Dec;42(6):1512-8.
doi: 10.1042/BST20140179.PubMed PMID: 25399562.

16: Hermann-Kleiter N, Baier G.
Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions.
Cell Commun. Signal. 2014 Jun12;12:38.
doi: 10.1186/1478-811X-12-38. Review. PubMed PMID: 24919548; PubMedCentral PMCID: PMC4066320.

17: Klepsch V, Hermann-Kleiter N, Baier G.
Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy.
Immunol Lett. 2016 Oct;178:31-6. doi: 10.1016/j.imlet.2016.03.007.PubMed PMID: 26992368.


  • (WO/2011/119062) CBLB AS PKCtheta MARKER
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